______ should be avoided when taking PPIs

______ should be avoided when taking PPIs

• A. Acetaminophen
• B. NSAIDs
• C. Antibiotics
• D. Laxatives

Answer: (B)

When you’re taking a proton pump inhibitor, you still want to limit drugs that can irritate the stomach lining. NSAIDs work by inhibiting prostaglandins, which protect the stomach, so they can cause gastritis, ulcers, and bleeding even if acid in the stomach is reduced by a PPI. The PPI lowers acid but doesn’t stop the mucosal damage NSAIDs can cause, so avoiding NSAIDs minimizes the risk of GI complications. Acetaminophen doesn’t affect the stomach lining in the same way and is generally safer for pain when a PPI is used. Antibiotics and laxatives don’t carry the same GI-injury risk tied to NSAIDs, so they’re not avoided for this reason.

When you’re taking a proton pump inhibitor, you still want to limit drugs that can irritate the stomach lining. NSAIDs work by inhibiting prostaglandins, which protect the stomach, so they can cause gastritis, ulcers, and bleeding even if acid in the stomach is reduced by a PPI. The PPI lowers acid but doesn’t stop the mucosal damage NSAIDs can cause, so avoiding NSAIDs minimizes the risk of GI complications.

Acetaminophen doesn’t affect the stomach lining in the same way and is generally safer for pain when a PPI is used. Antibiotics and laxatives don’t carry the same GI-injury risk tied to NSAIDs, so they’re not avoided for this reason.