Which antibiotic class is contraindicated in pregnancy due to effects on teeth?

Which antibiotic class is contraindicated in pregnancy due to effects on teeth?

• A. Tetracycline
• B. Macrolides
• C. Fluoroquinolones
• D. Aminoglycosides

Answer: (A)

Exposure to this antibiotic class during tooth development can cause permanent changes in teeth, so it’s contraindicated in pregnancy. Tetracyclines cross the placenta and become incorporated into calcifying teeth and bone by forming complexes with calcium. This leads to permanent yellow-to-brown discoloration of teeth and can disrupt enamel formation, with effects lasting into childhood. Because teeth are still forming in the fetus and in young children, avoidance is essential. The other classes don’t cause this specific teeth discoloration and enamel defect. Macrolides are generally considered safer options in pregnancy if antibiotics are needed. Fluoroquinolones are avoided due to potential cartilage damage to the developing fetus. Aminoglycosides carry risks of fetal hearing loss and kidney toxicity, but the hallmark teeth effects aren’t the primary reason they’re avoided.

Exposure to this antibiotic class during tooth development can cause permanent changes in teeth, so it’s contraindicated in pregnancy. Tetracyclines cross the placenta and become incorporated into calcifying teeth and bone by forming complexes with calcium. This leads to permanent yellow-to-brown discoloration of teeth and can disrupt enamel formation, with effects lasting into childhood. Because teeth are still forming in the fetus and in young children, avoidance is essential.

The other classes don’t cause this specific teeth discoloration and enamel defect. Macrolides are generally considered safer options in pregnancy if antibiotics are needed. Fluoroquinolones are avoided due to potential cartilage damage to the developing fetus. Aminoglycosides carry risks of fetal hearing loss and kidney toxicity, but the hallmark teeth effects aren’t the primary reason they’re avoided.